Fungicidal pyridyl amides

ABSTRACT

Novel fungicidal pyridyl amides carboxamides having the general structural formula ##STR1## wherein R is selected from the group consisting of C 3  -C 6  cycloalkyl, C 1  -C 4  alkyl, benzyl, substituted benzyl wherein the substitutions are selected from the group of C 1  -C 4  alkyl, C 1  -C 4  alkoxy, C 1  -C 4  alkanoyl, halogen, --NO 3  and C.tbd.N, C 2  -C 10  alkoxyalkyl, C 1  -C 4  haloalkyl, C 2  -C 8  alkenyl and alkanoyl; 
     R 1  is selected from the group consisting of halogen such as chlorine, fluorine and bromine, C 1  -C 3  alkoxy such as propoxyethoxy and methoxy, preferably methoxy and C 1  -C 3  haloalkoxy; 
     R 2  is selected from the group consisting of cyclopropyl, C 1  -C 6  alkyl, C 1  -C 6  alkoxy, C 2  -C 6  alkoxyalkoxy, C 1  -C 6  alkylthio, benzyl, substituted benzyl wherein the substitutions are selected from the group of C 1  -C 4  alkyl, C 1  -C 4  alkoxy, C 1  -C 4  alkanoyl, halogen, --NO 3  and C.tbd.N, and arylalkylthio; and 
     X is --O or --S; and 
     fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungicides are disclosed herein.

BACKGROUND OF THE INVENTION

Fungal infection of crops such as barley, rice, tomatoes, wheat, beans, roses, grapes and other agriculturally important crops can cause heavy losses in both quantity and quality of agricultural products. It is therefore extremely desirable to have means of preventing, controlling or eliminating fungal growth. Much preventive spraying with commercial fungicides is conducted to attempt to prevent the establishment and growth of fungi on agriculturally important crops. It would also be desirable to have a curative fungicide which, on detection of fungal infection, could control the fungi and eliminate the deleterious effects by use of a postinfection curative spray.

SUMMARY OF THE INVENTION

Novel fungicidal pyridyl amides having the formula ##STR2## wherein R is selected from the group consisting of C₃ -C₆ cycloalkyl, C₁ -C₄ alkyl, benzyl, substituted benzyl wherein the substitutions are selected from the group of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C.tbd.N, C₂ -C₁₀ alkoxyalkyl, C₁ -C₄ haloalkyl, C₂ -C₈ alkenyl and alkanoyl;

R₁ is selected from the group consisting of halogen such as chlorine, fluorine and bromine, C₁ -C₃ alkoxy such as propoxy, ethoxy and methoxy, preferably methoxy and C₁ -C₃ haloalkoxy;

R₂ is selected from the group consisting of cyclopropyl, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₂ -C₄ alkoxyalkoxy, C₁ -C₆ alkylthiobenzyl, substituted benzyl wherein the substitutions are selected from the group of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C.tbd.N, and arylalkylthio; and

X is --O or --S; and

fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungicides are disclosed herein.

The term "fungicide" is used to mean a compound which controls fungal growth. "Controls" includes prevention, destruction and inhibition of fungal growth. The term "curative" is meant to refer to a postinfection application of a fungicide which establishes control of fungal infection and prevents development of deleterious effects of the fungi on the host crop.

DETAILED DESCRIPTION

The novel fungicidal compounds of this invention are pyridyl cyclopropane carboximides having the general formula ##STR3## wherein R is selected from the group consisting of C₃ -C₆ cycloalkyl, C₁ -C₄ alkyl, benzyl, substituted benzyl wherein the substitutions are selected from the group of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C.tbd.N, C₂ -C₁₀ alkoxyalkyl, C₁ -C₄ haloalkyl, C₂ -C₈ alkenyl and alkanoyl;

R₁ is selected from the group consisting of halogen such as chlorine, fluorine and bromine, preferably chlorine, C₁ -C₃ alkoxy such as propoxy, ethoxy and methoxy, preferably methoxy and C₁ -C₃ haloalkoxy;

R₂ is selected from the group consisting of cyclopropyl, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₂ C₄ alkoxyalkoxy, C₁ -C₆ alkylthio, benzyl, substituted benzyl wherein the substitutions are selected from the group of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ C₄ alkanoyl, halogen, -NO₃ and C.tbd.N, and arylalkylthio; and

X is --O or --S; and

fungicidally acceptable organic and inorganic salts thereof which are highly effective fungicides for use both as preventive and curative fungicides are disclosed herein.

The compounds of this invention can be generally prepared by a multi-step reaction process. The first step comprises reacting an aminopyridine with the appropriate acid chloride or chloroformate in an inert polar solvent such as dichloromethane in a suitable reactor such as a glass reaction flask. It is desirable to maintain an acid scavenger such as pyridine in the reaction vessel. The reaction generally will proceed at room temperature but will operate at a temperature range from -30° to 80° C. The reaction should go to completion within 1 to 3 hours. The resulting intermediate product is recovered in a conventional manner by washing with an alkali solution such as sodium hydroxide and water, drying over conventional drying agents such as magnesium sulfate and crystallizing in hexane. The resulting amide is then reacted with a properly substituted haloalkyl ether in the presence of sodium hydride or other strong base in an inert solvent such as tetrahydrofuran (THF). Salts of the various pyridyl cyclopropane carboxamides can be conventionally prepared by reacting at least a molar amount of a Lewis acid with the carboxamide. Preferably the reaction is run in a solvent for the carboxamide. The prepared salt is recovered from the reaction mixture by conventional techniques.

Pyridyl carboxamides of the invention are basic. The unprotonated nitrogen atom of the pyridyl ring can be protonated by an acid, either organic or inorganic. Representative inorganic acids are hydrochloric, nitric, hydrobromic, sulfuric, sulfamic and phosphoric. Representative organic acids are acetic, trifluoroacetic, benzoic, benzenesulfonic, p-toluenesulfonic, naphthalenesulfonic, phenylphosphonic and organophosphonic. The salts so formed are also fungicidal.

EXAMPLE 1 Preparation of N-(2-Methoxy)-5-pyridyl)-cyclopropane carboxamide

5-amino-2-methoxy pyridine (12.4 g, 0.10 mol) and pyridine (10 ml) were mixed together in dichloromethane (200 ml) in a reaction flask. Cyclopropane carboxylic acid chloride (9.1 ml, 0.10 mol) was added to the reaction mixture over a period of 2 minutes. The reaction was exothermic and temperature rose to 34° C. The reaction was allowed to stand for one hour at room temperature, after which the reaction mixture was washed with 5% sodium hydroxide (200 ml) and water (100 ml). The resulting organic phase was separated and dried over anhydrous magnesium sulfate. Crystals formed, so the mixture was filtered and washed with acetone (300 ml) and the filtrate evaporated in vacuo to give a solid that was triturated with & ehxane to yield 16.7 g, after drying. The product was identified by infrared (IR) and nuclear magnetic resonance (NMR) analysis as the title compound, having a melting point of 130°-131° C.

EXAMPLE 2 Preparation of N-methoxyethoxymethyl-N-(2-methoxy-5-pyridyl)-cyclopropane carboxamide

Sodium hydride (0.33 g, 0.014 mol) and N-(2-methoxy-5-pyridyl)-cyclopropane carboxamide (92.5 g, 0.014 mol) were added to dry tetrahydrofuran (THF). This mixture was stirred under N2 for one hour when methoxyethyl chloromethyl ether (1.6 g, 0.014 mol) was added dropwise to the stirred mixture. The reaction was stirred overnight and diluted with ether and washed with water. The organic phase was dried over anhydrous magnesium sulfate, filtered, and evaporated in vacuo nto give 2.4 g of a yellow oil of the title compound. The structure was confirmed by mass spectroscopy (MS), IR and NMR analysis.

EXAMPLE 3 Preparation of N-(2-Methoxy-5-pyridyl)-N-(pivaloyloxymethyl)-cyclopropane carboxamide

Sodium hydride (0.5 g, 0.019 mol) was suspended in dry tetrahydrofuran followed by addition of N-(2-methoxy-5-pyridyl)-cyclopropane carboxamide and a gas was evolved. The reactoin was stirred for 20 minutes and then chloromethylpivalate (2.9 g, 0.019 mol) was added. The reaction was stirred for two hours until pH was near neutral, and then diluted with ether and washed with water. The ether phase was washed with water, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to give 3.4 g of a yellow oil. This was extracted with hexane leaving some residue and passed through a 1" pad of florisil. This gave an evaporation of the solvent in vacuo, 1.8 g of tht title compound as a yellow oil. The structure was confirmed by MS, IR and NMR analysis.

Representative compounds of this invention and their properties are shown in Table I.

                                      TABLE I                                      __________________________________________________________________________      ##STR4##                                                                      Cmpd.                                Physical                                  No. R         R.sub.1   R.sub.2   X  Properties                                __________________________________________________________________________     1   CH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3 SCH(CH.sub.3).sub.2                                                                      O  brown oil                                 2   CH.sub.2 CH.sub.2 OCH.sub.3                                                              OCH.sub.3 SCH(CH.sub.3).sub.2                                                                      O  brown oil                                 3   CH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                                 ##STR5## O  brown oil                                 4   CH.sub.2 CH.sub.2 OCH.sub.3                                                              OCH.sub.3                                                                                 ##STR6## O  yellow oil                                5   CH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3 SCH.sub.2 CH.sub.2 CH.sub.3                                                              O  brown oil                                 6   CH.sub.2 CH.sub.3                                                                        Cl                                                                                        ##STR7## O  brown oil                                 7   CH.sub.2 CH.sub.2 Cl                                                                     Cl                                                                                        ##STR8## O  brown oil                                 8    CH.sub.2 CH.sub.3                                                                       OCH.sub.3 CH.sub.2 CH.sub.3                                                                        O  yellow oil                                     ##STR9## OCH.sub.3                                                                                 ##STR10##                                                                               O  yellow oil                                10                                                                                  ##STR11##                                                                               OCH.sub.3                                                                                 ##STR12##                                                                               O  brown oil                                 11  CH.sub.3  OCH.sub.3                                                                                 ##STR13##                                                                               S  yellow oil                                12                                                                                  ##STR14##                                                                               OCH.sub.3                                                                                 ##STR15##                                                                               O  yellow oil                                13  CH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3 SCH.sub.3 O  yellow oil                                14  CH.sub.2 CH.sub.2 OCH.sub.3                                                              OCH.sub.3 SCH.sub.3 O  brown oil                                 15  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 SCH.sub.2 CH.sub.2 CH.sub.3                                                              O  brown oil                                 16  CH.sub.2 CH.sub.2 OCH.sub.3                                                              OCH.sub.3 SCH.sub.2 CH.sub.2 CH.sub.3                                                              O  brown oil                                 17  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 CH(CH.sub.3).sub.2                                                                       O  brown oil                                 18  CH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                                 ##STR16##                                                                               O  yellow oil                                19  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 SCH.sub.3 O  brown oil                                 20  CH.sub.2 CH.sub.3                                                                        OCH.sub.2 CHCH.sub.2                                                                     SCH.sub.2 CH.sub.3                                                                       O  orange oil                                21  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                                                              O  brown oil                                 22  CH.sub.2 CH.sub.3                                                                        OCH.sub.2 CH.sub.3                                                                        ##STR17##                                                                               O  yellow oil                                23  CH.sub.2 CH.sub.3                                                                        OCH.sub.2 CH.sub.3                                                                       SCH.sub.2 CH.sub.2 CH.sub.3                                                              O  yellow oil                                24  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 OCH.sub.2 CH(CH.sub.3).sub.2                                                             O  brown oil                                 25  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 OCH.sub.2 CH.sub.2                                                                       O  brown oil                                 26  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 OCH.sub.2 CH.sub.3                                                                       O  brown oil                                 27  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 OCH.sub.2 CH.sub.2 CH.sub.3                                                              O  brown oil                                 28  CH.sub.2 CH.sub.3                                                                        OCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3                                                             O  yellow oil                                29  CH.sub.3  OCH.sub.3 OCH.sub.2 CH.sub.2 OCH.sub.3                                                             O  brown oil                                 __________________________________________________________________________      cl EXAMPLE 4

Preventative Spray Evaluation Procedures Barley Powdery Mildew (PM)

Northrup King Sunbar 401 barley seed is planted (12 seeds/2" pot) in a sandy-loam soil seven days prior to testing. The test compound is diluted in a 50/50 acetone/water solution to produce concentrations decreasing from 2250 ug/ml. Twelve ml of test solution are sprayed onto the barley plants with atomizing sprayers.

Twenty-four hours later, test plants are placed in an inoculation box equipped with a circulating fan. Barley plants with heavily sporulating Erysiphe graminis lesions are placed in front of the fan to dislodge and distribute the spores. After two minutes the fan is shut off and the chamber is left closed five minutes for the spores to settle. Inoculated plants are then placed on an automatic sub-irrigation greenhouse bench.

Results are recorded seven days following inoculation as percent disease control based on the percent reduction in infected area as compared to the untreated control plants. Compound concentrations which provide 90% disease control (EC 90) are determined from dosage/dilution curves.

Rice Blast (RB)

Ten seeds of Calrose M-9 rice are planted in 2 inch pots in a sandy-loam soil 12 days prior to testing. The compound to be tested is diluited in a 50/50 acetone/water solution to produce concentrations decreasing from 2250 ug/ml. Twelve ml of test solution are sprayed onto the rice plants with atomizing sprayers.

Inoculum is produced from 3 week old cultures of Pyricularia oryzae, grown on Rice Polish agar. The agar is first flooded with deionized water, the spores rubbed off the surface, and then diluted to 5×10⁵ spore/ml in deionized water plux 0.05% Tween® 20. Plants are inoculated 24 hours after compound application by spraying with the spore suspension to runoff, allowing it to dry on the leaves, respraying to run-off, and then placing the plants into a dark mist chamber. Following 48 hours of mist, the plants are moved to an automatic subirrigation greenhouse bench.

Results are recorded seven days following inoculation as percent disease control based on the percent reduction in lesion area as compared to the untreated control plants. Compound concentrations which provide 90% disease control (EC 90) are estimated from dosage/dilution curves.

Botrytis Bud Blight (BB)

Two white rose petals are placed in a petri dish lined with wet filter paper. The compound to be tested is diluted with a 50/50 acetone/water solution to produce concentrations decreasing from 2250 ug/ml. One half ml of test solution is atomized onto the petals, and allowed to dry.

Inoculum is prepared by adding a 5 mm plug from a two-week old Botrytis cinerea culture grown on Elliot's V-8 agar, to 10 ml sterile distilled water plus 0.5 ml grape juice. A 20 ul drop of this inoculum suspension is placed on each petal. Petri dishes with inoculated petals are stored in sealed plastic boxes to maintain saturated humidity.

Results are read four days following inoculation as a percent reduction in necrotic area compared to the acebone/water controls. Compound concentrations which provide 90% disease control (EC 90) are determined from dosage/dilution curves.

Leaf Rust (LR)

Seven seeds of Anza wheat are planted in 2" pots in a sandy-loam soil 12 days prior to testing. The compound to be tested is diluted with a 50/50 acetone/water solution to produce concentrations decreasing from 2250 ug/ml. Twelve ml of test solution are sprayed onto the wheat plants with an atomizing sprayer.

A suspension of Puccinia recondita urediospores is prepared by vacuuming spores from wheat leaves with ureida pustules and suspending 10⁵ spores/ml in deionized water plus 0.5% Tween® 20 (polyoxyethylene sorbitan monolaurate). Plants are inoculated 24 hours after treatment by spraying with the spore suspension to runoff, allowing it to dry on the leaves, respraying to runoff, and then placing the plants into a mist chamber. Following 48 hours in the mist, plants are moved to a subirrigation greenhouse bench.

Results are recorded ten days following inoculation as percent disease control based on the percent reduction in lesion area as compared to the untreated control plants. Compound concentrations which provide 90% disease control (EC 90) are determined from dosage/dilution curves.

The results are presented in Table II as an approximate EC 90 in parts per million. 2250 ppm equals 2250 ug/ml. The entry (750) indicates partial control at 750 ppm. An asterisk (*) indicates no control at 750 ppm. The entry (2250) indicates partial control at 2250 ppm. Only selected compounds were tested at 2250 ppm.

                  TABLE II                                                         ______________________________________                                         Cmpd. No.   PM      RB        BB    LR                                         ______________________________________                                          1          *       (750)     *     *                                           2          *       *          (750)                                                                               *                                           3          *       *          (750)                                                                               *                                           4          *       *          (750)                                                                               *                                           5           (750)  *          (750)                                                                               *                                           6          *       *          (750)                                                                               *                                           7           (750)  *         *     *                                           8          *       *          (750)                                                                               *                                           9           750    *          750  *                                          10           750    *         *     *                                          11          *       *          750  *                                          12           (750)  *          83   *                                          13          2250    *         2250  2250                                       14          2250    *         (2250)                                                                               2250                                       15          (2250)  *         (2250)                                                                               2250                                       16          2250    *         (2250)                                                                               2250                                       17          2250    *         (2250)                                                                               (2250)                                     18          2250    *         2250  2250                                       19          2250    *         2250  2250                                       20          2250    *         (2250)                                                                               2250                                       21          *       *         *     2250                                       22          2250    *         (2250)                                                                               2250                                       23          *       *         *     *                                          24          *       *         *     2250                                       25          *       *         2250  2250                                       26          *       *         (2250)                                                                               2250                                       27          *       *         (2250)                                                                               (2250)                                     28          (2250)  *         *     (2250)                                     29          (2250)  *         *     2250                                       ______________________________________                                    

The compounds of this invention are particularly effective against Botrytis bud blight and are particularly effective as preventative foliar sprays and curative foliar sprays when compared to standard commercial compounds used as Botrytis preventative and curative sprays. Fungi on which the compounds of the present invention are also particularly effective are Erysiphe graminis and Pyricularia oryzae.

The compounds of the present invention are useful as fungicides, especially as preventative or curative fungicides, and can be applied in a variety of ways at various concentrations. In general, these compounds and formulations of these compounds can be applied directly to the crop foliage, the soil in which the crop is growing or in the irrigation water for the crop or soil. In practice, the compounds herein defined are formulated into fungicidal compositions, by admixture, in fungicidally effective amounts, with the adjuvants and carriers normally employed for facilitating the dispersion of active ingredients for agricultural applications, recognizing the fact that the formulation and mode of application of a toxicant may affect the activity of the materials in a given application. Thus, these active fungicidal compounds may be formulated as wettable powders, as emulsifiable concentrates, as powdery dusts, as solutions or as any of several other known types of formulations, depending upon the desired mode of application. Preferred formulations for preventative or curative fungicidal applications are wettable powders and emulsifiable concentrates. These formulations may contain as little as about 0.1% to as much as about 95% or more by weight of active ingredient. A fungicidally effective amount depends upon the nature of the seeds or plants to be treated and the rate of application varies from about 0.05 to approximately 25 pounds per acre, preferably from about 0.1 to about 10 pounds per acre.

Wettable powders are in the form of finely divided particles which disperse readily in water or other dispersants. The wettable powder is ultimately applied to the soil or plants either as a dry dust or as a dispersion in water or other liquid. Typical carriers for wettable powders include Fuller's earth, kaolin clays, silicas and other readily wet organic or inorganic diluents. Wettable powders normally are prepared to contain about 5% to about 95% of the active ingredient and usually also contain a small amount of wetting, dispersing, or emulsifying agent to facilitate wetting and dispersion.

Dry flowables or water dispersible granules are agglomerated wettable powders made by either pan granulation or by fluidized bed. The dry flowable is ultimately applied to the soil or plants as a dispersion in water or other liquid. These granules are dust-free and free flowing when dry and yet upon dilution in water, form homogeneous dispersions. Typical carriers for dry flowables include fuller's earth, kaolin clays, silicas and other readily wet organic or inorganic diluents. The dry flowables normally are prepared to contain from about 5% to about 95% of the active ingredient and usually contain a small amount of wetting, dispersing or emulsifying agent to facilitate wetting and dispersion.

Emulsifiable concentrates are homogeneous liquid compositions which are dispersible in water or other dispersant, and may consist entirely of the active compound with a liquid or solid emulsifying agent, or may also contain a liquid carrier, such as xylene, heavy aromatic naphtha, isophorone and other non volatile organic solvents. For fungicidal application, these concentrates are dispersed in water or other liquid carrier and normally applied as a spray to the area to be treated. The percentage by weight of the essential active ingredient may vary according to the manner in which the composition is to be applied, but in general comprises about 0.1% to 95% of active ingredient by weight of the fungicidal composition.

Typical wetting, dispersing or emulsifying agents used in agricultural formulations include, for example, the alkyl and alkylaryl sulfonates and sulfates and their sodium salts; polyhydroxy alcohols; and other types of surface-active agents, many of which are available in commerce. The surface-active agent, when used, normally comprises from 0.1% to 15% by weight of the fungicidal composition.

Dusts, which are free-flowing admixtures of the active ingredient with finely divided solids such as talc, clays, flours and other organic and inorganic solids which act as dispersants and carriers for the toxicant, are useful formulations for many applications.

Pastes, which are homogeneous suspensions of a finely divided solid toxicant in a liquid carrier such as water or oil, are employed for specific purposes. These formulations normally contain about 5% to about 95% of active ingredient by weight, and may also contain small amounts of a wetting, dispersing or emulsifying agent to facilitate dispersion. For application, the pastes are normally diluted and applied as a spray to the area to be affected.

    ______________________________________                                         EXAMPLES OF TYPICAL FORMULATIONS                                               Ingredient            Weight %                                                 ______________________________________                                         Oil                                                                            Compound 1             1                                                       Oil solvent-heavy aromatic naphtha                                                                    99                                                      Total                 100                                                      Emulsifiable Concentrate                                                       Compound 2            50                                                       Kerosene              45                                                       Emulsifying agent (mixture of long                                                                    5                                                       chain ethoxylated polyethers with                                              long chain sulfonate)                                                          Total                 100                                                      ______________________________________                                         Emulsifiable Concentrate                                                       Compound 3            90                                                       Kerosene              5                                                        Emulsifying agent (mixture of long                                                                   5                                                        chain ethoxylated polyethers with                                              long chain sulfonate)                                                          Total                 100                                                      Dusts and/or Powders                                                           Ingredient          Wt. %   Wt. %   Wt. %                                      ______________________________________                                         Compound 4          0.5     50.0    90.0                                       Attapulgite Clay Powder                                                                            93.5    44.0    4.0                                        Sodium lignin sulfonate                                                                            5.0     5.0     5.0                                        Sodium dioctyl sulfosuccinate                                                                      1.0     1.0     1.0                                        Total               100.0   100.0   100.0                                      ______________________________________                                    

Other useful formulations for fungicidal applications include simple solutions of the active ingredient in a dispersant in which it is completely soluble at the desired concentration, such as acetone, alkylated naphthalenes, xylene and other organic solvents. Pressurized sprays, typically aerosols, wherein the active ingredient is dispersed in finely divided form as a result of vaporization of a low boiling dispersant solvent carrier, such as the Freons, may also be used.

The fungicidal compositions of this invention are applied to the plants in the conventional manner. Thus, the dust and liquid compositions can be applied to the plant by the use of power-dusters, boom and hand sprayers and spray dusters. The compositions can also be applied from airplanes as a dust or a spray because they are effective in low dosages. 

We claim:
 1. A compound having the structural formula ##STR18## wherein R is selected from the group consisting of C₃ -C₆ cycloalkyl, C₁ -C₄ alkyl, benzyl, substituted benzyl wherein the substituents are selected from the group consisting of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C.tbd.N; C₂ -C₁₀ alkoxyalkyl, C₁ -C₄ haloalkyl and C₂ -C₈ alkenyl and C₂ -C₈ alkanoyl;R₁ is selected from the group consisting of halogen, C₁ -C₃ alkoxy, and C₁ -C₃ haloalkoxy; R2 is selected from the group consisting of cyclopropyl, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₂ -C₆ alkoxyalkoxy, C₁ -C₆ alkylthio, benzyl, substituted benzyl wherein the substituents are selected from the group consisting of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C N; and X is --O or --S; or a fungicidally acceptable organic or inorganic salt thereof.
 2. The compound of claim 1 wherein R is -CH₂ CH₃, R₁ is -OCH₃, R₂ is -CH₂ CH₃ and X is O.
 3. The compound of claim 1 wherein R is ##STR19## R₁ is -OCH₃, R₂ is ##STR20## and X is O.
 4. The compound of claim 1 wherein R is ##STR21## R₁ is -OCH₃, R₂ is ##STR22## and X is O.
 5. A fungicidal composition comprising a fungicidally effective amount of a compound having the structural formula ##STR23## wherein R is selected from the group consisting of C₃ -C₆ cycloalkyl, C₁ -C₄ alkyl, benzyl, substituted benzyl wherein the substituents are selected from the group consisting of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C.tbd.N; C₂ -C₁₀ alkoxyalkyl, C₁ -C₄ haloalkyl and C₂ -C₈ alkenyl and C₂ -C₈ alkanoyl;R₁ is selected from the group consisting of halogen, C₁ -C₃ alkoxy, and C₁ -C₃ haloalkoxy; R2 is selected from the group consisting of cyclopropyl, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₂ -C₆ alkoxyalkoxy, C₁ -C₆ alkylthio, benzyl, substituted benzyl wherein the substituents are selected from the group consisting of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C N; and X is --O or --S; or a fungicidally acceptable organic or inorganic salt thereof and an inert diluent carrier therefor.
 6. The method of controlling fungi comprising applying to the area where control is desired, a fungicidally effective amount of a compound having the formula ##STR24## wherein R is selected from the group consisting of C₃ -C₆ cycloalkyl, C₁ -C₄ alkyl, benzyl, substituted benzyl wherein the substituents are selected from the group consisting of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C.tbd.N; C₂ -C₁₀ alkoxyalkyl, C₁ -C₄ haloalkyl and C₂ -C₈ alkenyl and C₂ -C₈ alkanoyl;R₁ is selected from the group consisting of halogen, C₁ -C₃ alkoxy, and C₁ -C₃ haloalkoxy; R2 is selected from the group consisting of cyclopropyl, C₁ -C₆ alkyl, C₁ -C₆ alkoxy, C₂ -C₆ alkoxyalkoxy, C₁ -C₆ alkylthio, benzyl, substituted benzyl wherein the substituents are selected from the group consisting of C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkanoyl, halogen, -NO₃ and C N; and X is --O or --S; or a fungicidally acceptable organic or inorganic salt thereof.
 7. The method of claim 6 wherein R is -CH₂ CH₃, R₁ is -OCH₃, R₂ is -CH₂ CH₃ and X is O.
 8. The method of claim 6 wherein R is ##STR25## R₁ is -OCH₃, R₂ is ##STR26## and X is O.
 9. The method of claim 6 wherein R is ##STR27## R₁ is -OCH3, R₂ is ##STR28## and X is O. 